16-F-0021_DOC_05_DARPA_Enabling_Stress_Resistance-ESR.pdf

Enabling Stress Resistance (ESR) COL Christian Macedonia Program Manager, DARPA/DSO 2/18/2016 1 Distribution Statement -- 1 of 22 -- Optimal Performance Adaptive Negative ESR Overview 2 A substantive understanding of what moderates the stress response is a prerequisite to promoting resilience and preventing stress-provoked cognitive dysfunction. Examples of fundamental questions that should drive these investigations are: 1. What are the mechanisms involved that afford an initial resistance to s...