16-F-0021_DOC_02_BioChronicity.pdf

Approved for Public Release, Distribution Unlimited 1 BioChronicity (BioC): Chronotherapeutics Plasmodium clocks Cell cycle Developmental Metabolic Host clocks Innate response (e.g., TNF-Į, IL-6) Circadian systems Synchronous erythrocyte bursting every 48 hr Clock-based therapy: Asynchronizing the clocks between host and parasite will reduce parasite fitness Targets of 56/100 WHO essential medicines & best-selling drugs are clock-regulated (half-life often < 6 hours) Example: anti-hypertensive d...